Abstract Colombia has experienced a non-international armed conflict which has lasted for more than 60 years. On September 4, 2012, during the presidential term of Juan Manuel Santos, peace negotiations began between the Colombian State and the Revolutionary Armed Forces of Colombia -People's Army (FARC-EP) - with the aim of ending the armed conflict between both actors. The agreements culminated on September 26, 2016. Regarding the foregoing, questions arose on the criminal liability of the State agent. The question on their liability has resounded in the competent international bodies, such as the International Criminal Court and the Inter-American Court of Human Rights. The recently created Special Jurisdiction for Peace (JEP) is now to decide the possible activation of the principle of complementarity to avoid delays in processes involving high-ranking State officials and properly comply with the provisions of Article 120, Statute of Rome.

Resumen Colombia ha vivido un conflicto armado de carácter no internacional que ha durado más de 60 años. El 4 de septiembre de 2012, durante el periodo presidencial de Juan Manuel Santos, se iniciaron las negociaciones de paz entre el Estado colombiano y las Fuerzas Armadas Revolucionarias de Colombia -Ejército del Pueblo (FARC-EP)-, con el objetivo de terminar el conflicto armado entre ambos actores. Los acuerdos culminaron el 26 de septiembre de 2016. Con ello surgieron cuestionamientos en los que se reclama la responsabilidad de los agentes del Estado. La cuestión en torno a dicha responsabilidad ha retumbado en las instancias internacionales competentes, como la Corte Penal Internacional y la Corte Interamericana de Derechos Humanos. La recientemente creada Jurisdicción Especial para la Paz (JEP) es ahora la encargada de dirimir la posible activación del principio de complementariedad para evitar dilaciones en los procesos que involucren altos mandos del Estado y, así, cumplir lo dispuesto en el artículo 120 del Estatuto de Roma.

RESUMEN Objetivo. Resumir los resultados de las investigaciones realizadas en Costa Rica en las que se aplicaron métodos matemáticos y estadísticos para estudiar la dinámica de transmisión de las enfermedades transmitidas por mosquitos. Métodos. Se seleccionaron y analizaron tres artículos con análisis matemáticos y estadísticos sobre enfermedades transmitidas por vectores en Costa Rica. En estos artículos se muestra el valor y la pertinencia de emplear diferentes métodos cuantitativos para comprender la dinámica de la enfermedad y brindar apoyo a la toma de decisiones. Resultados. Los resultados de estas investigaciones: 1) muestran la repercusión en los informes de casos de dengue cuando surge un segundo agente patógeno, como el chikunguña; 2) recuperan parámetros clave en la dinámica del Zika mediante la inferencia bayesiana; y 3) muestran el uso de los algoritmos de aprendizaje automático y las variables climáticas para pronosticar el riesgo relativo de dengue en cinco lugares diferentes. Conclusiones. Los modelos matemáticos y estadísticos permiten describir la dinámica de transmisión de las enfermedades transmitidas por mosquitos, mediante la provisión de información cuantitativa para brindar apoyo a los métodos de prevención y control y a la planificación de la asignación de recursos.

ABSTRACT Objective. To summarize the results of research conducted in Costa Rica in which mathematical and statistical methods were implemented to study the transmission dynamics of mosquito-borne diseases. Methods. Three articles with mathematical and statistical analysis on vector-borne diseases in Costa Rica were selected and reviewed. These papers show the value and relevance of using different quantitative methods to understand disease dynamics and support decision-making. Results. The results of these investigations: 1) show the impact on dengue case reports when a second pathogen emerges, such as chikungunya; 2) recover key parameters in Zika dynamics using Bayesian inference; and 3) show the use of machine learning algorithms and climatic variables to forecast the dengue relative risk in five different locations. Conclusions. Mathematical and statistical modeling enables the description of mosquito-borne disease transmission dynamics, providing quantitative information to support prevention/control methods and resource allocation planning.

RESUMO Objetivo. Resumir os resultados de estudos realizados na Costa Rica em que foram aplicados métodos matemáticos e estatísticos para estudar a dinâmica de transmissão de doenças transmitidas por mosquitos. Métodos. Foram selecionados e revisados três artigos com análises matemáticas e estatísticas sobre doenças transmitidas por vetores na Costa Rica. Esses artigos mostram o valor e a pertinência do uso de diferentes métodos quantitativos para compreender a dinâmica das doenças e apoiar a tomada de decisões. Resultados. Os resultados dessas investigações: 1) mostram o impacto nas notificações de casos de dengue quando surge um segundo patógeno, como o chikungunya; 2) recuperam parâmetros-chave na dinâmica do zika, usando a inferência bayesiana; e 3) mostram o uso de algoritmos de aprendizagem por máquina e variáveis climáticas para prever o risco relativo da dengue em cinco locais diferentes. Conclusões. A modelagem matemática e estatística permite a descrição da dinâmica de transmissão de doenças transmitidas por mosquitos ao oferecer informações quantitativas para apoiar métodos de prevenção e/ou controle e o planejamento da alocação de recursos.

ABSTRACT This study aimed to find sources of resistance to damping-off and to determine the inheritance of resistance in watermelon. Firstly, 72 watermelon accessions were inoculated with CMM 1053 isolate of Rhizoctonia solani. Only two accessions (BGH 29 and BGH 76) were considered moderately resistant to the disease. The inoculated plants without symptoms from accession BGH-29 identified as resistant were self-fertilized and the inbred line S1 was used for the crosses. The reaction to R. solani after inoculation of the segregating populations of the cross and backcrosses between susceptible cultivar Crimson Sweet and the inbred line BGH-29 was evaluated. In other experiment eight S1 lines of watermelon were inoculated with six different isolates of R. solani and the reaction was evaluated by partial diallel analysis using the Griffing’s method IV to obtain estimates of general resistance ability (GRA), general aggressiveness ability (GAA), and specific interaction ability (SIA). According to ratings of the susceptible and resistant parents, generations F1, F2, BC1 (F1 × P1) and BC2 (F1 × P2), resistance to damping-off was conferred by at least nine genes with additive effect and low heritability which indicates polygenic inheritance. The results of the diallel analysis corroborate with the analysis of segregating population, indicating inheritance of resistance was horizontal, since 46.1% of the total sum of squares of the variation observed in the crosses was due to GRA, while the SIA corresponded to only 20.39% of variation. This is the first report about inheritance of resistance to damping-off caused by R. solani in watermelon.

RESUMO Objetivo: A profilaxia e o tratamento da ossificação heterotópica ainda são controversos. O objetivo desta pesquisa foi avaliar a efetividade das intervenções para prevenir o desenvolvimento da ossificação heterotópica após a fixação cirúrgica das fraturas do acetábulo. Métodos: Foi realizada uma revisão sistemática com pesquisa nas bases de dados PubMed/MEDLINE, Embase, LILACS e Cochrane até 4 de agosto de 2020, sem restrições quanto ao idioma e ano de publicação. Foram incluídos apenas ensaios clínicos randomizados realizados em humanos sem restrições com base na dosagem dos tratamentos, no uso e na duração da profilaxia. Cálculos de metanálise foram realizados utilizando o software Review Manager desenvolvido pela Cochrane. Resultados: Dois estudos compararam o uso de radioterapia e indometacina e três compararam o uso de indometacina com um grupo placebo ou não indometacina. Os cálculos de metanálise não indicaram diferenças estatísticas entre radioterapia versus indometacina (RR 1.45, IC de 95% 0.97 a 2.17, p = 0,55) e indometacina versus placebo ou não indometacina (RR 0.85, IC de 95% 0.68 a 1.06, p = 0,59). Conclusão: Não há evidências suficientes para afirmar que a utilização da radioterapia ou da indometacina é efetiva para prevenir a formação da ossificação heterotópica após cirurgias por fraturas do acetábulo. Além disso, o número de complicações foi maior no grupo indometacina quando comparado ao placebo ou à não intervenção. Nível de Evidência I, Revisão Sistemática.

ABSTRACT Objective: Heterotopic ossification is defined as the formation of trabecular bone in soft tissues. It is a common complication after surgical treatment of acetabular fractures. However, its prophylaxis and treatment are still controversial. The objective of this research is to evaluate the effectiveness of actions to prevent the development of heterotopic ossification after surgical correction of acetabular fractures. Methods: A systematic review was carried out with research in the databases PubMed/MEDLINE, Embase, LILACS and Cochrane until August 4, 2020, without restrictions on language and year of publication. Only randomized clinical studies carried out in humans without restrictions based on the dosage of treatments, use and duration of prophylaxis were included in this review. Results: Two studies compared the use of radiotherapy and indomethacin and three compared the use of indomethacin with a placebo or non-indomethacin group. The meta-analysis calculations did not indicate statistical differences between radiotherapy versus indomethacin (RR 1.45, IC 95% 0.97 to 2.17, p = 0,55) and indomethacin versus placebo or not indomethacin (RR 0.85, IC 95% 0.68 to 1.06, p = 0,59). Conclusion: There is insufficient evidence to affirm that the use of radiotherapy or indomethacin are effective to prevent the formation of heterotopic ossification after surgery for fractures of the acetabulum. In addition, the number of complications was higher in the indomethacin group when compared to placebo or no intervention. Level of Evidence I, Systematic Review.

ABSTRACT Recent studies suggested that cannabis use influences on the emergence of psychosis by disrupting neurodevelopmental processes that occur during adolescence and early adulthood and which are reflected on brain anatomical changes detectable with MRI. However, no MRI studies have investigated whether intrauterine neurodevelopmental abnormalities also interact with later cannabis use to influence on psychosis risk. We investigated differences between first-episode psychosis (FEP) patients with history of cannabis use (FEPC+, n=28), FEP subjects without cannabis use (FEPC-, n=78) and healthy controls (n=80) in regard to the frequency of absent or short Adhesio Interthalamica (AI), a well-established marker of intrauterine neurodevelopment. The FEPC+ subgroup had a significantly lower prevalence of absent AI than FEPC- subjects, as well as a lack of a significantly shorter AI length compared to controls (as found in FEPC- subjects). These preliminary results show that psychosis subjects with cannabis use present a low rather than high frequency of absent AI, suggesting that fixed intrauterine neurodevelopmental abnormalities may not be associated with cannabis use later in life to influence on the emergence of psychosis. This is consistent with a view that multiple different etiological processes may lead to similar clinical presentations in patients with FEP.

Resumo: O presente artigo objetiva tratar sobre a forma como o ódio colonial vem sendo historicamente capitaneado pelo capitalismo, perpetuando, a partir do Estado moderno, uma estrutura racial e sexista que alijam pessoas negras, mulheres e LGBT. Ainda que interseccionada, iremos nos deter no ódio direcionado às pessoas transgêneros, sujeitos cujo controle da vida e dos corpos tem revelado ódio como projeto de Estado neoliberal que promove a invisibilidade e o extermínio dessas pessoas.

Abstract: This article aims to deal with the way colonial hatred has been historically dominated by capitalism, perpetuating from the Modern State a racial and sexist structure that black people, women and LGBT. Although intersected, we will focus on hatred toward transgender people, subjects whose control of their lives and bodies has revealed Hatred as a neoliberal state project that promotes their invisibility and extermination.

Resumen Se construye un modelo epidémico para la dinámica de transmisión de la fiebre del dengue con etapa temprana de vida en los vectores y estructura de edad en las clases de los huéspedes. La etapa de vida temprana del vector, se modela a través de una función general que admite múltiples densidades de vectores. El número reproductivo básico y vector de umbral demográfico, se calculan para estudiar la estabilidad local y global del estado libre de infección. Se implementa además un marco numérico y se realizan simulaciones.

Abstract We construct an epidemic model for the transmission of dengue fever with an early-life stage in the vector dynamics and age-structure within hosts. The early-life stage of the vector is modeled via a general function that supports multiple vector densities. The basic reproductive number and vector demographic threshold are computed to study the local and global stability of the infection-free state. A numerical framework is implemented and simulations are performed.

Resumen La propagación de enfermedades infecciosas y su impacto en individuos juega un gran rol en la dinámica de enfermedades, y es importante incorporar heterogeneidad en la población en los esfuerzos por estudiar enfermedades. De manera simplística pero ilustrativa, se examinan interacciones entre una población urbana y una rural en la dinámica de la propagación de una enfermedad. Utilizando un sistema compartimental de dinámicas entre susceptibles-infectados-susceptibles (SIeS) con cierto nivel de inmunidad, se formula un modelo que permite reinfecciones no lineales. Se investiga los efectos de movimiento de poblaciones en un escenario simple: un caso con dos poblaciones, que permite modelar movimiento entre un área urbana y otra rural. Con el fin de estudiar la dinámica del sistema, se calcula el número básico reproductivo para cada comunidad (rural y urbana). Se calculan también puntos de equilibrio, la estabilidad local del estado libre de enfermedad, y se identifican condiciones para la existencia de estados de equilibrio endémicos. Del análisis y experimentos computacionales, se ilustra que el movimiento en la población juega un rol importante en la dinámica del sistema. En algunos casos, puede ser beneficioso, pues incrementa la región de estabilidad del punto de equilibrio del estado libre de infección.

Abstract The propagation of infectious diseases and its impact on individuals play a major role in disease dynamics, and it is important to incorporate population heterogeneity into efforts to study diseases. As a simplistic but illustrative example, we examine interactions between urban and rural populations on the dynamics of disease spreading. Using a compartmental framework of susceptible-infected-susceptible (SI S ) dynamics with some level of immunity, we formulate a model that allows nonlinear reinfection. We investigate the effects of population movement in a simple scenario: a case with two patches, which allows us to model population movement between urban and rural areas. To study the dynamics of the system, we compute a basic reproduction number for each population (urban and rural). We also compute steady states, determine the local stability of the disease-free steady state, and identify conditions for the existence of endemic steady states. From our analysis and computational experiments, we illustrate that population movement plays an important role in disease dynamics. In some cases, it can be rather beneficial, as it can enlarge the region of stability of a disease-free steady state.

Resumen Durante décadas, el virus del dengue ha causado grandes problemas a los funcionarios de salud pública en países tropicales y subtropicales de todo el mundo. Construimos un modelo compartimental que incluye el papel de las personas hospitalizadas en la dinámica de transmisión del dengue en Costa Rica. Calculamos el número básico reproductivo, ℛ 0 , así como un análisis de sensibilidad en los parámetros de ℛ 0 y discutimos la importancia de las políticas de salud pública. Se establece la estabilidad local y global del estado libre de enfermedad. Se hacen simulaciones numéricas bajo escenarios específicos para determinar estrategias óptimas de prevención y control.

Abstract For decades, dengue virus has caused major problems for public health officials in tropical and subtropical countries around the world. We construct a compartmental model that includes the role of hospitalized individuals in the transmission dynamics of dengue in Costa Rica. The basic reproductive number, ℛ 0 , is computed, as well as a sensitivity analysis on ℛ 0 parameters. The global stability of the disease-free equilibrium is established. Numerical simulations under specific parameter scenarios are performed to determine optimal prevention/control strategies.

Resumen En países tropicales y subtropicales alrededor del mundo, el clima ha sido un factor fundamental en moldear la distribución geográfica e incidencia de los casos de dengue. En Costa Rica, un país tropical con múltiples microclimas, el dengue ha sido endémico desde 1993, con repercusiones no solo en el ámbito de la salud, sino también en el social y económico. Utilizando el número de casos de dengue y los datos climáticos del 2007- 2017, ajustamos un modelo predictivo mediante un enfoque de Modelo Aditivo Generalizado y bosques aleatorios, el cual nos permitió predecir de forma retrospectiva el riesgo relativo de dengue en cinco cantones alrededor del país.

Abstract Climate has been an important factor in shaping the distribution and incidence of dengue cases in tropical and subtropical countries. In Costa Rica, a tropical country with distinctive micro-climates, dengue has been endemic since its introduction in 1993, inflicting substantial economic, social, and public health repercussions. Using the number of dengue reported cases and climate data from 2007-2017, we fitted a prediction model applying a Generalized Additive Model (GAM) and Random Forest (RF) approach, which allowed us to retrospectively predict the relative risk of dengue in five climatological diverse municipalities around the country.

Resumo: O objetivo deste trabalho foi determinar o efeito da suplementação de L-carnitina no desempenho produtivo e na fisiologia de juvenis de pacu (Piaractus mesopotamicus). Um total de 288 pacus, com peso inicial médio de 9,62±0,74 g, foram alimentados com dietas experimentais suplementadas com 400, 800, 1.200, 1.600 e 2.000 mg kg-1 de L-carnitina e com uma dieta controle (sem suplementação), por 128 dias. Foram avaliados: desempenho produtivo; composição centesimal da carcaça; histomorfologias intestinal, muscular e hepática; e estresse oxidativo. Os índices hepatossomático e de gordura viscerossomática dos peixes aumentaram com a inclusão de L-carnitina nas rações. A avaliação da composição centesimal da carcaça mostrou que as dietas suplementadas com 2.000 mg kg-1 de L-carnitina causaram redução no conteúdo de proteína e aumento no de extrato etéreo. A histomorfologia intestinal indicou alterações nas vilosidades com a suplementação de L-carnitina. Além disso, a peroxidação lipídica hepática ocorreu com a inclusão de 2.000 mg kg-1 de L-carnitina. A suplementação de L-carnitina em dietas para juvenis de pacu não influencia o desenvolvimento dos peixes até a dose de 1.600 mg kg-1. Entretanto, observam-se elevados níveis de lipídeos na carcaça, assim como aumento nos índices hepatossomáticos e de gordura viscerossomática, em peixes alimentados com rações contendo 2.000 mg kg-1.

Abstract: The objective of this work was to determine the effect of L-carnitine supplementation on the productive performance and physiology of juvenile pacu (Piaractus mesopotamicus). A total of 288 pacu, with an initial average weight of 9.62±0.74 g, were fed experimental diets supplemented with 400, 800, 1,200, 1,600, and 2,000 mg kg-1 L-carnitine and a control diet (without supplementation), for 128 days. The following were evaluated: growth performance; carcass centesimal composition; intestinal, muscle, and hepatic histomorphologies; and oxidative stress. The fish hepatosomatic and viscerosomatic fat indexes increased with the inclusion of L-carnitine in the diets. The evaluation of carcass centesimal composition showed that the diets supplemented with 2,000 mg kg-1 L-carnitine caused a reduction in protein content and an increase in that of ethereal extract. Intestinal histomorphology indicated changes in the villi with L-carnitine supplementation. Moreover, hepatic lipid peroxidation occurred with the inclusion of 2,000 mg kg-1 L-carnitine. The supplementation with L-carnitine in the diets of pacu juveniles does not influence the development of the fish until the rate of 1,600 mg kg-1. However, high carcass lipid levels, as well as an increase in the hepatosomatic and viscerosomatic fat indexes, are observed in fish fed diets containing 2,000 mg kg-1.

BACKGROUND The five BRICS (Brazil, Russian, Indian, China, and South Africa) countries bear 49% of the world’s tuberculosis (TB) burden and they are committed to ending tuberculosis. OBJECTIVES The aim of this paper is to map the scientific landscape related to TB research in BRICS countries. METHODS Were combined bibliometrics and social network analysis techniques to map the scientific publications related to TB produced by the BRICS. Was made a descriptive statistical data covering the full period of analysis (1993-2016) and the research networks were made for 2007-2016 (8,366 records). The bubble charts were generated by VantagePoint and the networks by the Gephi 0.9.1 software (Gephi Consortium 2010) from co-occurrence matrices produced in VantagePoint. The Fruchterman-Reingold algorithm provided the networks’ layout. FINDINGS During the period 1993-2016, there were 38,315 peer-reviewed, among them, there were 11,018 (28.7%) articles related by one or more authors in a BRICS: India 38.7%; China 23.8%; South Africa 21.1%; Brazil 13.0%; and Russia 4.5% (The total was greater than 100% because our criterion was all papers with at least one author in a BRICS). Among the BRICS, there was greater interaction between India and South Africa and organisations in India and China had the highest productivity; however, South African organisations had more interaction with countries outside the BRICS. Publications by and about BRICS generally covered all research areas, especially those in India and China covered all research areas, although Brazil and South Africa prioritised infectious diseases, microbiology, and the respiratory system. MAIN CONCLUSIONS An overview of BRICS scientific publications and interactions highlighted the necessity to develop a BRICS TB research plan to increase efforts and funding to ensure that basic science research successfully translates into products and policies to help end the TB epidemic.

Resumen Antecedentes: El costo de la alimentación en piscicultura pueden superar el 70% del costo total. Las industrias de alimentos para peces han intentado formular dietas balanceadas con subproductos de menor valor en el mercado para minimizar costos. Objetivo: Evaluar la harina de girasol como sucedáneo parcial (0, 10 y 20%) de la torta de soya, suplementada o no con fitasa (1.500 FTU/kg) en dietas isoprotéicas (27% de PB) e isoenergéticas 3400 kcal / ED / kg de ración) para bagre (barbudo, Col.; Rhamdia quelen). Métodos: Los peces, 360 juveniles (15,77 ± 0,56 g), se distribuyeron aleatoriamente en 24 unidades experimentales, en un diseño completamente al azar, en esquema factorial (3x2) y 4 repeticiones. A los 90 días se evaluó: desempeño productivo, variables hematológicas, histología de tejido intestinal y composición bromatológica de la carcasa y de la materia mineral de los huesos. Resultados: La inclusion de 20% de harina de girasol mejoró la ganancia de peso de los peces y la tasa de eficiencia proteica de la ración, sin diferencia para las otras evaluaciones ni interacción entre los demás factores evaluados. Conclusión: La harina de girasol se puede utilizar en un 20% de la ración del bagre (barbudo, Col.) como sucedáneo a la harina de soja. La inclusión de fitasa (1.500 FTU/kg) no mejoró el valor nutritivo de estas raciones.

Abstract Background: The cost of feed in fish farming can exceed 70% of the total costs. Thus, the feed industry have sought to formulate balanced diets including low-cost by-products. Objective: To evaluate sunflower meal as a partial substitute (0, 10, and 20%) for soybean meal, with or without phytase supplementation (1,500 FTU/kg) in isoproteic (27% crude protein (CP)) and isoenergetic diets (3,400 kcal/ED/kg of feed) for silver catfish (Rhamdia quelen) juveniles. Methods: A total of 360 fish (weight: 15.77 ± 0.56 g) were randomly distributed in 24 tanks in a completely randomized design following a factorial scheme (3x2) with 4 replicates. The fish were evaluated on the following variables after 90 days: productive performance, hematological variables, histology of intestinal tissue, bromatological composition of carcass, and composition of bone mineral matter. Results: 20% dietary inclusion of sunflower meal improved weight gain and protein efficiency. No difference was observed in the other treatments and no interactions were observed between the other factors. Conclusion: 20% sunflower meal can be included in the feed of silver catfish as a substitute for soybean meal. Phytase inclusion (1,500 FTU/kg) did not improve the nutritional value of the treatments.

Resumo Antecedentes: Os custos relativos a alimentação na piscicultura pode ultrapassar 70% do custo final, neste sentido, as indústrias de rações têm procurado formular dietas balanceadas com subprodutos de menor valor de mercado para minimizar estes custos. Objetivo: Esse estudo objetivou avaliar o farelo de girassol como sucedâneo parcial (0, 10 e 20%) do farelo de soja, suplementado ou não com a fitase (1.500 FTU/kg), em dietas isoprotéicas (27% de PB) e isoenergéticas (3400 kcal/ED/kg de ração) para o jundiá (Rhamdia quelen). Métodos: Os peixes, 360 juvenis (15,77 ± 0,56 g) foram distribuídos aleatoriamente em 24 unidades experimentais, num delineamento inteiramente casualizado, em esquema fatorial (3x2) e 4 repetições. Após 90 dias foram avaliados: desempenho produtivo, variáveis hematológicas, histologia de tecido intestinal, composição bromatológica da carcaça e de matéria mineral dos ossos. Resultados: O emprego de 20% de farelo de girassol melhorou o ganho de peso dos peixes e a taxa de eficiência protéica da ração, sem diferença nas outras avaliações, ou para a interação entre os demais fatores avaliados. Conclusão: Pode-se concluir que o farelo de girassol pode ser utilizado em 20% da ração do jundiá, como sucedâneo ao farelo de soja e, que a inclusão de fitase (1,500 FTU/kg) não melhorou o valor nutritivo destas rações.

Abstract Aim: The aim of this study was to assess the external load of amateur male players during 4 consecutive training microcycles (M) at the beginning of the in-season according to the training session in absolute external load demands and in relation to the competition demands. Methods: Regional-level players (n = 10; age, 20.8 ± 1.7 years; height, 175.5 ± 3.8 cm; body mass, 69.7 ± 2.9 kg; soccer experience, 13.2 ± 2.5 years) were monitored using GPS devices during training sessions and matches. The external load variables measured were: duration (min); total distance covered (TD); distance covered at high-speed (HID, 14.4-19.8 km/h); distance covered at sprinting (SPD; >19.8 km/h); and distance covered in high intensity acceleration (ACD; >2.5 m/s2) and deceleration (DECD; <-2.5 m/s2). Results: The results indicated that the external load variables (time, HID, SPD, ACD, and DECD) were similar between the four microcycles. Greater (p<0.01) time, TD, HID and SPD were observed in match day (MD)-2 compared to MD+1, MD-3, and MD-1. Aside from training duration, all external loads variables (TD, HID, SPD, ACD, and DECD) were lower during training sessions compared to official matches (p<0.05). Conclusion: Amateur soccer players present relative stable external training loads across competitive microcycles, with the peak load observed two days before the official match. Besides this, the match constitutes the highest load during a typical competitive microcycle in this cohort of players.

ABSTRACT Purpose: Although the worldwide percutaneous nephrolithotomy (PCNL) practice pat- terns determined via a survey sent to members of the Endourological Society have been published, differences in PCNL practice patterns among Latin American urologists based on endourological or lithiasis training have not been published. To determine the PCNL practice patterns among Latin American urologists with and without training in endourology. Materials and Methods: The SurveyMonkey® web platform was used to develop a 27-item survey on PCNL for the treatment of renal stones, and the survey was sent via e- -mail and other electronic media to 2000 urologists from 15 Latin American countries. Endourology-trained (group 1) and nontrained urologists (group 2) were analyzed. The group results were compared using the chi-squared and Fisher's exact tests. SPSS version 20 for Windows was used for all analyses. Results: A total of 331 urologists responded to the survey (rate of 16.55%): 221 (66.7%) in group 1 and 110 (33.2%) in group 2). In groups 1 and 2, 91.9% and 63.2% performed PCNL, respectively: 85.1% and 58.5% used preoperative tomography, respectively; 12.7% and 4.7% used preoperative nephrolitometry nomograms, respectively: 45.2% and 32.1% used endoscopic combined intrarenal surgery, respectively: 68.3% and 38.7% used mul- tiple percutaneous tract realization, respectively: and 19.9% and 5.7% used minimally invasive PCNL, respectively (all p=0.0005). Conclusions: Statistically significant differences were observed in PCNL practice patterns of Latin American urologists with and without training in endourology. Specific training in endourology significantly influence the practice patterns of Latin American urologists.